July 7th 2022

Published in MDPI: Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

Published in MDPI: Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

The CARE partners Katholieke Universiteit Leuven (KUL), Universiteit Utrecht (UU), University Of Dundee (UNIVDUN), Universitaet Zu Luebeck (UZL) in collaboration with a number of other organisations published a paper reporting on the conduct of a high-throughput screening of a 160 K compound library against SARS-CoV-2, yielding a promising hit. Antiviral profiling revealed this candidate was active against various beta-coronaviruses and preliminary mode-of-action experiments demonstrated that it interfered with viral entry.

To learn more, click here: Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication