December 6th 2021

CARE paper published in Journal of Virology: New insights for assessment of SARS-CoV-2 infection estimates and (vaccine-induced) antibody durability response

CARE paper published in Journal of Virology: New insights for assessment of SARS-CoV-2 infection estimates and (vaccine-induced) antibody durability response 

CARE researchers have determined SARS-CoV-2-specific antibody responses to different proteins (trimeric spike protein, monomeric spike protein and nucleocapsid protein) in sera of people infected with COVID-19 in acute-infection and post-infection phases. The results suggest that in order to generate correct estimates of SARS-CoV-2 infections in the general population, it is better to test for a specific type of antibody response, i.e. the antibodies that are generated in response to the trimeric spike protein as opposed to the monomeric spike protein and the nucleocapsid protein. Furthermore, the assessment of antibody responses against the trimeric spike protein will be critical to evaluate the durability of the antibody response for the characterization of a vaccine-induced antibody response.

To learn more, read the paper in the Journal of Virology: Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies